tag:blogger.com,1999:blog-5350157389434430698.post4650824387413734397..comments2024-02-27T21:23:44.159-08:00Comments on A Three-Pound Monkey Brain: Another "All Your Yesterdays" entry: Denisovan, or "Polar Neandertal"Mike Keeseyhttp://www.blogger.com/profile/00147156174467903264noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-5350157389434430698.post-6187018528057309912013-03-06T15:00:21.556-08:002013-03-06T15:00:21.556-08:00There are a few problems with what you say.
1) I-...There are a few problems with what you say.<br /><br />1) I-M253 (formerly I1) is a Y-DNA haplogroup. To the best of my knowledge, there is no Y-DNA known for Denisovans. (The only sampled individual was female.)<br /><br />2) All known human Y-DNA haplogroups (including the recently discovered A00 branch) originated after the initial split between humans and Denisovans.<br /><br />3) If someone did have a Denisovan Y chromosome, it would be over 95% Denisovan, since the Y chromosome does not recombine. (The only exception is some [noncoding] parts of the telomeres, which do recombine with the X chromosome. Although the X chromosome has very little Denisovan DNA even in native Australians and New Guineans.)<br /><br />Are you sure you're reading the report right?Mike Keeseyhttps://www.blogger.com/profile/00147156174467903264noreply@blogger.comtag:blogger.com,1999:blog-5350157389434430698.post-7360379338742814432013-03-06T09:26:42.948-08:002013-03-06T09:26:42.948-08:00A polar Neandertal. Maybe a good guess?
The Deniso...A polar Neandertal. Maybe a good guess?<br />The Denisovan genes is not only found in Australia etc.<br />My I1 haplogroup (Norwegian) have 4.2% Denisovan genes, according to Geno 2.0Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5350157389434430698.post-63004658598405462432013-03-03T08:53:14.279-08:002013-03-03T08:53:14.279-08:00This comment has been removed by a blog administrator.Lowongan Kerjahttp://www.karirkoe.comnoreply@blogger.comtag:blogger.com,1999:blog-5350157389434430698.post-90331139755567882062013-02-28T15:36:01.122-08:002013-02-28T15:36:01.122-08:00FWIW, 23andMe predicted my eyes to be brown. (They...FWIW, 23andMe predicted my eyes to be brown. (They're green.)Mike Keeseyhttps://www.blogger.com/profile/00147156174467903264noreply@blogger.comtag:blogger.com,1999:blog-5350157389434430698.post-46398848379993274602013-02-28T15:35:09.840-08:002013-02-28T15:35:09.840-08:00Aha!
"However, we note that predicted phenot...Aha!<br /><br />"However, we note that predicted phenotypes in Cerqueira et al. did not show a strong concordance with observed phenotypes in modern humans (total percentage of agreement = 59%) and the reliability of the inference for the Denisovan individual (belonging to an archaic group that might have had other pigmentation-associated SNPs not present in modern human variation) may be even lower."<br /><br />So event at best we aren't even 60% sure of the inferred pigmentation.Mike Keeseyhttps://www.blogger.com/profile/00147156174467903264noreply@blogger.comtag:blogger.com,1999:blog-5350157389434430698.post-25876294681768049852013-02-28T15:16:31.413-08:002013-02-28T15:16:31.413-08:00After all, a certain other hominine has sexually d...After all, <a href="http://images.fineartamerica.com/images-medium-large/silverback-gorilla-r7917-wingsdomain-art-and-photography.jpg" rel="nofollow">a certain other hominine has sexually dimorphic males with reduced hair pigmentation</a>.Mike Keeseyhttps://www.blogger.com/profile/00147156174467903264noreply@blogger.comtag:blogger.com,1999:blog-5350157389434430698.post-33527630708104070472013-02-28T15:11:31.930-08:002013-02-28T15:11:31.930-08:00He is actually pretty human-looking once you get p...He is actually pretty human-looking once you get past the expression and the hair distribution.<br /><br />As to the other point ... hmmm ... in that case I'll posit a mutation elsewhere in the regulatory network, previously unidentified due to its uniformity in humans! And maybe I'll place it on the Y chromosome, currently unknown for Denisovans! Yeah!Mike Keeseyhttps://www.blogger.com/profile/00147156174467903264noreply@blogger.comtag:blogger.com,1999:blog-5350157389434430698.post-85773317634293541532013-02-28T11:59:36.264-08:002013-02-28T11:59:36.264-08:00Hi Mike,
Cool reconstruction, but I am sorry to sa...Hi Mike,<br />Cool reconstruction, but I am sorry to say, we actually have a lot of information on what Denisovans could have look like, thanks to the recently published high coverage genome. There is a freely accessible supplementary table to the paper with inferred pigmentation patterns at odds with your reconstruction (http://www.sciencemag.org/content/suppl/2012/08/29/science.1224344.DC1/Meyer.SM.pdf). They were inferred to have dark skin, dark hair and brown eyes (and not freckles!). Not bad for a pinky finger. <br />I also imagine them much more human than your reconstruction. <br />Josie Hammet got it right in an illustration for a piece in the Guardian<br />http://www.guardian.co.uk/science/2010/mar/26/siberia-new-human-being<br />Good luck with your entry though.<br />The Denisova genome paper is:<br /> Meyer, M., Kircher, M., Gansauge, M. T., Li, H., Racimo, F., Mallick, S., ... & Pääbo, S. (2012). A high-coverage genome sequence from an archaic denisovan individual. Science.Africa Gomezhttps://www.blogger.com/profile/03501193251810926737noreply@blogger.com